Perkinil is a prescription medication containing Procyclidine Hydrochloride, which belongs to the class of antimuscarinic (anticholinergic) antiparkinsonian agents. It is primarily used as an adjunctive treatment for all forms of Parkinsonism and to control extrapyramidal symptoms caused by neuroleptic drugs. Produced by Square Pharmaceuticals PLC, it is one of the most widely prescribed medications for muscle control and rigidity.
What is Perkinil Used For?
Perkinil is specifically formulated to address neurological movement issues:
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Parkinson’s Disease: Treatment of idiopathic (paralysis agitans), postencephalitic, and arteriosclerotic parkinsonian symptoms.
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Drug-Induced Symptoms: Control of extrapyramidal effects such as pseudo-parkinsonism, acute dystonic reactions (muscle spasms), and akathisia (restlessness) caused by antipsychotic medications.
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Muscle Rigidity: Helping to relax stiff muscles and improve body posture for smoother movement.
Clinical Insight: Procyclidine works by correcting the relative cholinergic excess in the brain, which occurs due to dopamine deficiency. Recent neurological reviews emphasize its efficacy in restoring balance in the neurotransmitter system. For more technical data on its action mechanism, you can visit DrugBank.
Dosage
For optimal results and to reduce side effects, Perkinil should ideally be taken after meals.
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Parkinsonism: Initially 2.5 mg three times daily. This can be increased to 5 mg three times daily, and occasionally a dose is added at bedtime.
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Drug-Induced Symptoms: Initially 2.5 mg three times daily, increasing by 2.5 mg daily increments as tolerated until symptoms are controlled.
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Maximum Dose: The total daily dose typically ranges between 20 mg to 30 mg, divided into 3-4 doses.
Common Side Effects
At standard doses, Perkinil is generally well-tolerated, but common effects include:
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Dry Mouth: The most frequent side effect.
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Blurred Vision: Due to pupil dilation (mydriasis).
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Gastrointestinal Issues: Nausea, vomiting, or constipation.
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Dizziness: Lightheadedness and occasional vertigo.
2026 Safety Update: High doses may lead to confusion, agitation, or hallucinations, particularly in elderly patients. Research published in the Journal of Neurology suggests that monitoring intraocular pressure is essential for patients with a history of eye sensitivity. Detailed safety profiles are available via the Mayo Clinic.
Important Warnings & Precautions
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Glaucoma & Urinary Retention: Use with extreme caution in patients with narrow-angle glaucoma or prostate issues.
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No Abrupt Stopping: Do not stop taking Perkinil suddenly, as it may cause a rebound of Parkinsonian symptoms.
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Mental Health: Patients with existing mental disorders should be monitored, as it may occasionally precipitate psychotic episodes.
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Pregnancy: Safety during pregnancy and breastfeeding is not established; use only if the benefits clearly outweigh the risks.
Perkinil vs. Perkirol: Key Differences and Usage
It is important not to confuse Perkinil (Procyclidine) with Perkirol (Ropinirole), as they have different mechanisms of action.
| Feature | Perkinil (Procyclidine) | Perkirol (Ropinirole) |
| Drug Class | Antimuscarinic / Anticholinergic | Dopamine Agonist |
| Primary Use | Muscle Rigidity & Drug Side Effects | Idiopathic Parkinson’s & RLS |
| Mechanism | Reduces Acetylcholine Activity | Stimulates Dopamine Receptors |
| Side Effects | Dry mouth, Blurred vision | Fainting, Nausea, Drowsiness |
| Unit Price (5mg) | ৳1.25 | ৳6.00+ (for 2mg) |
Perkinil Price in Bangladesh (January 2026 Update)
The following table provides the updated pricing for Perkinil variants by Square Pharmaceuticals.
| Product Name | Strength | Unit Price (BDT) | Strip Price (20 Tabs) |
| Perkinil 5 | 5 mg | ৳1.25 | ৳25.00 |
| Perkinil Inj. | 10 mg/2 ml | ৳35.00 | ৳35.00 (per ampoule) |
Perkinil Alternative Brands & Prices
Here are 10 top alternative brands of Procyclidine 5mg available in Bangladesh as of 2026:
| Brand Name | Company Name | Price per Unit (BDT) |
| Cyclid 5 | Incepta Pharmaceuticals | ৳1.00 |
| Kdrin 5 | Opsonin Pharma Ltd. | ৳1.00 |
| Extranil 5 | General Pharmaceuticals | ৳0.98 |
| Rocy 5 | Doctor TIMS Pharma | ৳1.00 |
| Prokacin 5 | Kemiko Pharmaceuticals | ৳1.00 |
| Proclidin 5 | Silva Pharmaceuticals | ৳1.00 |
| Cyclidine 5 | Jayson Pharmaceuticals | ৳0.95 |
| Kemadrin 5 | GSK Bangladesh | ৳1.76 |
| Procyclin 5 | Rephco Pharmaceuticals | ৳0.90 |
| Dinil 5 | Hudson Pharmaceuticals | ৳0.95 |
Frequently Asked Questions (FAQ) About Perkinil
Q: What is the Perkinil 5 mg price in Bangladesh?
As of January 2026, the retail price for Perkinil 5 is ৳1.25 per tablet, and a strip of 20 tablets costs ৳25.00.
Q: What is Perkinil used for?
It is used to treat all forms of Parkinson’s disease and to control extrapyramidal symptoms (like tremors and muscle spasms) caused by other medications.
Q: What are the side effects of Perkinil?
Common side effects include dry mouth, blurred vision, nausea, and constipation. At high doses, confusion or dizziness may occur.
Q: Is Perkinil safe during pregnancy?
Safety has not been established. It should only be used if prescribed by a specialist who has weighed the benefits against potential risks. Further info is on the
Q: What is the recommended Perkinil dose?
The initial dose is usually 2.5 mg three times daily, taken after meals, and adjusted by a doctor up to 20-30 mg daily.
Q: Does Perkinil make you sleepy?
It can cause dizziness or decreased alertness; users should avoid driving until they know how the medication affects them.
Q: Can Perkinil be used for children?
Safety and efficacy in children are not well established; it is generally used for adults unless specified by a specialist.
Q: Can I stop taking Perkinil suddenly?
No, sudden withdrawal can lead to a severe return of symptoms. Always taper off under medical guidance.
Q: Are there alternatives to Perkinil in Bangladesh?
Yes, common alternatives include Cyclid 5, Kdrin 5, and Extranil 5, with prices ranging from ৳0.90 to ৳1.00 per tablet.
Disclaimer: This is educational information only (updated January 2026). Not a substitute for professional medical advice. Always consult a qualified physician before starting or stopping any medication.
