Osartil 50 Plus is a prescription combination medication containing Losartan Potassium (50 mg) and Hydrochlorothiazide (12.5 mg). It is primarily used to treat high blood pressure (hypertension) when monotherapy is insufficient. Losartan is an Angiotensin II Receptor Blocker (ARB) that relaxes blood vessels, while Hydrochlorothiazide is a thiazide diuretic that helps the body remove excess salt and water. Produced by Incepta Pharmaceuticals Ltd., it is a cornerstone in cardiovascular care in Bangladesh as of early 2026.
What is Osartil 50 Plus Used For?
Osartil 50 Plus is indicated for the effective management of blood pressure and associated heart risks:
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Hypertension: Treatment of essential hypertension in patients whose blood pressure is not adequately controlled on Losartan or Hydrochlorothiazide alone.
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Stroke Risk Reduction: Indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (thickening of the heart’s left ventricle).
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Cardiovascular Protection: Helping to prevent future heart attacks and kidney failure by maintaining stable blood pressure levels.
Key Reminder: Osartil 50 Plus is a maintenance medication and should be taken daily as prescribed. It is not for the acute treatment of a hypertensive crisis. For technical pharmacological data, visit the DrugBank Losartan Profile.
Dosage
For adults requiring hypertension management:
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Standard Dose: One tablet (50/12.5 mg) once daily.
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Maximum Dose: If blood pressure remains uncontrolled after 2 to 4 weeks, the dosage may be increased to one tablet of 100/25 mg daily (Osartil 100 Plus).
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Administration: Can be taken with or without food. Because it contains a diuretic, it is best taken in the morning to avoid nighttime urination.
Common Side Effects
Osartil 50 Plus is generally well-tolerated, though some patients may experience:
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Dizziness or lightheadedness (especially when rising from a sitting position)
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Fatigue or general weakness
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Upper respiratory tract infection or cough
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Nausea or stomach upset
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Back pain
Important Warnings & Precautions
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No Alcohol: Avoid alcohol, as it can increase the blood-pressure-lowering effect and cause severe dizziness or orthostatic hypotension.
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Kidney/Liver Health: Use with caution in patients with impaired liver function or moderate kidney disease. Contraindicated in severe kidney failure (Anuria).
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Dehydration: Thiazide diuretics can cause fluid loss. Ensure adequate hydration unless otherwise directed.
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Diabetic Monitoring: May affect blood glucose levels; diabetic patients should monitor their sugar more closely.
Osartil 50 Plus vs. Angilock Plus: Key Differences and Usage
While both are common brands of Losartan/HCTZ in Bangladesh, they are manufactured by different leading companies.
| Feature | Osartil 50 Plus | Angilock Plus |
| Manufacturer | Incepta Pharmaceuticals Ltd. | Square Pharmaceuticals PLC |
| Active Ingredients | Losartan 50mg + HCTZ 12.5mg | Losartan 50mg + HCTZ 12.5mg |
| Primary Use | Hypertension & Stroke Risk | Hypertension & Stroke Risk |
| Action Mechanism | ARB + Thiazide Diuretic | ARB + Thiazide Diuretic |
| Unit Price | ৳10.00 | ৳10.00 |
Osartil 50 Plus Price (February 2026 Update)
The following table provides the updated retail pricing for Osartil 50 Plus by Incepta Pharmaceuticals Ltd.
| Product Name | Strength | Unit Price (BDT) | Strip Price (10 Tablets) |
| Osartil 50 Plus | 50 mg + 12.5 mg | ৳10.00 | ৳100.00 |
| Osartil 100 Plus | 100 mg + 25 mg | ৳12.00 | ৳120.00 |
Osartil 50 Plus Alternative Brands & Prices
If Osartil 50 Plus is unavailable, these 50/12.5 mg alternatives are widely available in Bangladesh as of early 2026.
| Brand Name | Company Name | Price per Unit (BDT) |
| Angilock Plus | Square Pharmaceuticals | ৳10.00 |
| Prosan HZ | Beximco Pharmaceuticals | ৳8.00 |
| Losardil 50/12.5 | Drug International Ltd | ৳8.05 |
| Losacor Plus | Healthcare Pharmaceuticals | ৳10.00 |
| Ostan Plus | Renata PLC | ৳9.50 |
| Larb Plus | Opsonin Pharma | ৳10.00 |
| CardoPlus | Eskayef (SK+F) | ৳10.00 |
| Losan Plus | Orion Pharma Ltd | ৳8.02 |
| Losatan HZ | Popular Pharmaceuticals | ৳8.00 |
| Losart Plus | The ACME Laboratories Ltd | ৳9.00 |
Frequently Asked Questions (FAQ) About Osartil 50 Plus
Q: What is the Osartil 50 Plus price in Bangladesh?
As of February 2026, the retail price for Osartil 50 Plus is ৳10.00 per tablet. A full strip of 10 tablets costs ৳100.00.
Q: What is Osartil 50 Plus used for?
It is used to treat high blood pressure (hypertension) and to reduce the risk of stroke in patients with hypertension and a thickened heart muscle (left ventricular hypertrophy).
Q: What are the side effects of Osartil 50 Plus?
Common side effects include dizziness, fatigue, headache, and nausea. Due to the diuretic component, it will cause increased urination, which is its intended function to lower blood pressure.
Q: Is Osartil 50 Plus safe during pregnancy?
No. Osartil 50 Plus is strictly contraindicated during pregnancy (especially after the first 3 months) as it can cause serious injury or death to the unborn baby.
Q: What is the recommended Osartil 50 Plus dose?
The standard starting dose is one tablet (50/12.5) once daily. It should be taken at the same time every day, preferably in the morning to avoid waking up at night to urinate.
Q: What does Osartil 50 Plus do to the body?
It relaxes blood vessels (via Losartan) and reduces the total amount of fluid in your blood vessels (via Hydrochlorothiazide), both of which lower blood pressure.
Q: Does Osartil 50 Plus make you sleepy?
It can cause dizziness or tiredness, particularly during the first few days of treatment. Do not drive or operate machinery if you feel less alert than usual.
Q: Is Osartil 50 Plus high risk?
It is considered a safe treatment. However, it is high risk for pregnant women, those with severe kidney/liver failure, or those with anuria (unable to pass urine).
Q: Are there any alternatives to Osartil 50 Plus in Bangladesh?
Yes, common alternatives include Angilock Plus (Square), Prosan HZ (Beximco), and CardoPlus (Eskayef), with prices typically between ৳8.00 and ৳10.00.
Disclaimer: This is educational information only (updated February 2026). Not a substitute for professional medical advice. Always consult a qualified physician before starting/stopping any medication.
