Xyril 25 is a first-generation sedating antihistamine containing Hydroxyzine Hydrochloride. It is a versatile medication used to treat both physical allergic reactions and psychological symptoms like anxiety. It works by blocking histamine H1-receptors and suppressing activity in certain subcortical regions of the central nervous system. In Bangladesh, it is manufactured by Opsonin Pharma Ltd. and is widely recognized for its dual-action benefits.
What is Xyril 25 Used For?
Xyril 25 mg is specifically prescribed for adults and children over 6 years old to manage:
-
Anxiety and Tension: Symptomatic relief of anxiety associated with psychoneurosis or as an adjunct in organic disease states.
-
Pruritus (Itching): Management of severe itching caused by allergic conditions such as chronic urticaria (hives), atopic dermatitis, and contact dermatitis.
-
Pre-operative Sedation: Used as a sedative premedication before and after general anesthesia to help patients relax.
-
Chronic Hives: Effective in reducing redness and swelling in long-term skin allergies.
Crucial Note: Unlike non-sedating antihistamines like Fenadin, Xyril 25 has significant sedative properties. It is often used when an allergy or anxiety condition prevents a patient from sleeping or staying calm.For a deeper look into the clinical profile of this molecule, you can review the pharmacology of Hydroxyzine on DrugBank.
Dosage
For adults and children, the dosage must be strictly determined by a physician based on the condition:
-
For Anxiety: Adults typically take 50–100 mg (2 to 4 tablets) daily in divided doses.
-
For Itching/Allergies: Adults usually start with 25 mg (one tablet) at night, which may be increased to 3 to 4 times daily as needed.
-
Pre-operative Sedation: Adults are generally given a single dose of 50–100 mg.
-
Administration: Can be taken with or without food. If it causes stomach upset, taking it with a meal is recommended.
Common Side Effects
Xyril 25 is a sedating medication, and side effects are common:
-
Most Common: Drowsiness (often disappears after a few days of continued use), dry mouth, and tiredness.
-
Central Nervous System: Headache, dizziness, and psychomotor impairment.
-
Anticholinergic Effects: Blurred vision, constipation, or urinary retention in some elderly patients.
-
Safety Tip: Due to severe drowsiness, do not drive or operate heavy machinery after taking Xyril 25.
Important Warnings & Precautions
-
Alcohol Interaction: Avoid alcohol entirely; it significantly increases the sedative effects of Xyril, which can lead to dangerous levels of respiratory depression.
-
Drug Interactions: Xyril can increase the effects of other CNS depressants like narcotics, barbiturates, and antidepressants.
-
Heart Rhythm: Use with caution if you have a history of heart rhythm problems (QT prolongation), as hydroxyzine may slightly increase this risk.
-
Kidney/Liver Health: Dosage adjustments are required for patients with renal or hepatic impairment.
Xyril 25 vs. Monas 10: Key Differences
| Feature | Xyril 25 (Hydroxyzine) | Monas 10 (Montelukast) |
| Drug Class | First-Gen Antihistamine | Leukotriene Antagonist |
| Primary Goal | Acute Itching & Anxiety | Asthma & Allergy Prevention |
| Onset | Fast (15–30 minutes) | Slow (Maintenance) |
| Drowsiness | High / Sedating | Non-sedating |
| Approx. Price | ৳2.30 | ৳17.50 |
Xyril Tablet Price in Bangladesh (January 2026 Update)
Pricing for the Xyril range by Opsonin Pharma remains affordable for the 2026 period.
| Product Name | Strength | Unit Price (BDT) | Strip Price (20 Tablets) |
| Xyril 25 | 25 mg | ৳2.30 | ৳46.00 |
| Xyril 10 | 10 mg | ৳1.50 | ৳30.00 |
| Xyril Syrup | 10mg/5ml | ৳45.00 (100ml) | N/A |
Top 10 Alternative Brands & Prices
If Xyril 25 is unavailable, the following are the top-rated 25 mg Hydroxyzine alternatives in Bangladesh as of early 2026.
| Brand Name | Company Name | Price per Unit (BDT) |
| Roxyzin 25 | Incepta Pharmaceuticals | ৳2.00 |
| Artica 25 | ACI Limited | ৳3.00 |
| Urtizin 25 | UniMed UniHealth | ৳2.00 |
| H-Zine 25 | Square Pharmaceuticals | ৳2.50 |
| Hydrox 25 | Beximco Pharmaceuticals | ৳2.50 |
| Atarax 25 | Radiant (Under License) | ৳5.00 |
| Zyzine 25 | Renata Limited | ৳2.50 |
| Axizine 25 | Aristopharma Ltd. | ৳2.20 |
| Hydrax 25 | Delta Pharma | ৳2.00 |
| Ryzin 25 | Popular Pharmaceuticals | ৳2.30 |
Frequently Asked Questions (FAQ) About Xyril 25
What is the current Xyril 25 price in Bangladesh?
As of January 2026, the retail price for Xyril 25 is ৳2.30 per tablet. A standard strip of 20 tablets costs approximately ৳46.00.
What is Xyril 25 used for?
It is used to treat severe itching (pruritus) caused by allergies and for the symptomatic relief of anxiety and tension. It is also used as a sedative before or after surgery.
What are the common Xyril 25 side effects?
The most common side effects are drowsiness, dry mouth, and headache. Less common effects include dizziness, constipation, or blurred vision.
Is Xyril 25 safe during pregnancy?
Xyril 25 is contraindicated in early pregnancy. Clinical data is inadequate to establish safety, so it should only be used if clearly necessary and prescribed by a doctor later in pregnancy. Consult your physician for safer alternatives.
How quickly does Xyril 25 start working?
It is rapidly absorbed, with clinical effects typically noticed within 15 to 30 minutes after taking the tablet.
Can I take Xyril 25 for sleep?
While it is very sedating and often helps with sleep, it is not primarily marketed as a sleeping pill. You should only use it for sleep if specifically directed by a doctor for an underlying allergy or anxiety condition.
Can I take Xyril 25 with alcohol?
No. Alcohol significantly increases the sedative effects of Xyril 25, which can lead to excessive sleepiness and impaired breathing.
Is Xyril 25 safe for the elderly?
Elderly patients are more sensitive to the side effects, such as confusion or urinary retention. Doctors usually recommend starting with half the standard dose.
Is it different from Fexo or Monas?
Yes. Fexo is a non-drowsy antihistamine for hay fever, and Monas is for asthma prevention. Xyril is a sedating antihistamine that also treats anxiety.
Disclaimer: This content is for educational purposes based on January 2026 data. It is not a substitute for professional medical advice. Always consult a qualified physician before starting or switching any medication.
