Motigut 10 is a prescription medication containing Domperidone Maleate, a dopamine antagonist with gastroprokinetic properties. It is primarily used to treat symptoms of indigestion and to prevent nausea and vomiting. Produced by the leading manufacturer Square Pharmaceuticals PLC, Motigut 10 works by increasing the movements of the stomach and intestines, allowing food to move more easily through the digestive system.
What is Motigut 10 Used For?
Motigut 10 mg is formulated for adults and children (with weight-based adjustments) to address upper gastrointestinal issues. Its primary applications include:
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Nausea and Vomiting Relief: Effective for nausea caused by various factors, including migraine, radiotherapy, or drug therapy.
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Dyspeptic Symptoms: Treatment of bloating, upper abdominal pain, flatulence, and early satiety (feeling full too quickly).
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GERD Management: Reducing heartburn and acid regurgitation associated with gastroesophageal reflux disease.
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Gastroparesis: Helping the stomach empty more effectively when movement is slowed down.
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Parkinson’s Disease Support: Managing nausea induced by dopamine-agonist medications used in Parkinson’s treatment.
Clinical Insight: Domperidone acts on the peripheral dopamine receptors in the stomach and the “vomiting center” of the brain (CTZ). Because it has poor penetration of the blood-brain barrier, it has fewer neurological side effects than older alternatives. For technical data, visit the National Library of Medicine (NIH) – Domperidone Profile.
Dosage
For adults and adolescents (12 years and older, weighing 35 kg or more), the standard dosage is one 10 mg tablet three times daily.
The medication should be taken 15 to 30 minutes before meals for maximum absorption. In acute cases of nausea, the dose may be increased up to 20 mg (2 tablets) every 6 to 8 hours, but the total daily dose should not exceed 80 mg. The maximum treatment duration for acute symptoms is usually 12 weeks. Always follow the specific instructions provided by your gastroenterologist.
Common Side Effects
Motigut 10 is generally well-tolerated when taken at recommended doses. However, as it affects hormone levels related to prolactin, some users may notice:
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Dry mouth
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Headache or dizziness
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Mild intestinal cramps or diarrhea
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Breast tenderness or enlargement (rare)
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Irregular menstrual periods in women
Important Warnings & Precautions
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Heart Conditions: Contraindicated in patients with congestive heart failure or known heart rhythm problems.
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GI Bleeding: Do not use if you have mechanical obstruction, perforation, or active gastrointestinal bleeding.
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Liver Health: Since it is highly metabolized in the liver, use with extreme caution in patients with hepatic impairment.
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Prolactinoma: Strictly avoid if you have a prolactin-releasing pituitary tumor.
Motigut 10 vs. Entacyd Plus: Key Differences and Usage
Patients often take both for stomach issues, but they serve different roles in the digestive process.
| Feature | Motigut 10 (Domperidone) | Entacyd Plus (Antacid) |
| Drug Class | Prokinetic (Motility Stimulant) | Antacid & Anti-flatulent |
| Primary Use | Nausea & Gastric Emptying | Acidity, Gas & Heartburn |
| Action Mechanism | Stimulates stomach muscles | Neutralizes stomach acid |
| Timing | 30 mins before meals | 1 hour after meals |
| Unit Price | ৳ 4.00 | ৳ 1.50 – ৳ 2.50 |
Motigut 10 Price (January 2026 Update)
Pricing for the Motigut range by Square Pharmaceuticals PLC remains stable in the early 2026 market.
| Product Name | Strength | Unit Price (BDT) | Strip Price (10 Tablets) |
| Motigut 10 | 10 mg | ৳ 4.00 | ৳ 40.00 |
| Motigut 5 | 5 mg | ৳ 2.50 | ৳ 25.00 |
| Motigut Susp. | 5 mg/5 ml | ৳ 40.00 | 60 ml Bottle |
Motigut 10 Alternative Brands & Prices
If Motigut 10 is unavailable, several high-quality alternatives with the same generic are available in Bangladesh.
| Brand Name | Company Name | Price per Unit (BDT) |
| Omidon 10 | Incepta Pharmaceuticals | ৳ 3.50 |
| Deflux 10 | Beximco Pharmaceuticals | ৳ 4.00 |
| Don-A 10 | The ACME Laboratories | ৳ 3.50 |
| Domin 10 | Opsonin Pharma Limited | ৳ 3.50 |
| Efodio 10 | Radiant Pharmaceuticals | ৳ 4.50 |
| Ridon 10 | Eskayef (SK+F) | ৳ 3.50 |
| Vave 10 | ACI Limited | ৳ 4.00 |
| Dopadon 10 | Ibn Sina Pharmaceuticals | ৳ 3.00 |
| Apuldon 10 | Aristopharma Ltd. | ৳ 3.50 |
| Domiren 10 | Renata PLC | ৳ 3.50 |
Frequently Asked Questions (FAQ) About Motigut 10
1. What is the Motigut 10 mg price in Bangladesh?
As of January 2026, the retail price is ৳ 4.00 per tablet. A standard strip of 10 tablets costs ৳ 40.00.
2. What are the common side effects of Motigut 10?
Common side effects include dry mouth, headache, and intestinal cramps. In rare cases, it can cause breast tenderness or changes in libido due to increased prolactin levels.
3. What is Motigut 10 used for?
It is used to treat nausea, vomiting, indigestion (dyspepsia), and bloating. It helps the stomach empty faster, reducing the feeling of fullness and reflux.
4. Is Motigut 10 safe during pregnancy?
Generally, no. The safety of Domperidone during pregnancy has not been proven. It should be avoided unless a doctor determines the benefits outweigh the risks. Animal studies show no birth defects, but human data is insufficient.
5. Can Motigut 10 increase breast milk supply?
Yes, it is sometimes used off-label to increase lactation because it increases prolactin levels. However, this should only be done under strict medical supervision due to potential heart risks.
6. Does Motigut 10 make you sleepy?
Drowsiness is rare but possible. If you feel dizzy or sleepy after taking it, avoid driving or operating heavy machinery.
7. What is the recommended Motigut 10 dose?
For adults, the standard dose is one 10 mg tablet, three times a day, taken 15-30 minutes before meals.
8. Is Motigut 10 high risk for heart patients?
Yes. It is considered high risk for those with heart rhythm disorders (QT prolongation) or heart failure. It is also restricted for individuals over 60 years old at higher doses.
9. Are there any alternatives to Motigut 10 in Bangladesh?
Yes, high-quality alternatives include Omidon (Incepta), Deflux (Beximco), and Don-A (ACME), with prices ranging from ৳ 3.00 to ৳ 4.50.
Disclaimer: This is educational information only (updated January 2026). Not a substitute for professional medical advice. Always consult a qualified physician before starting/stopping any medication.
