Amodis 400 is a potent antimicrobial medication containing Metronidazole 400 mg. It belongs to the nitroimidazole class of antibiotics and is highly effective against anaerobic bacteria and protozoa. Manufactured by Square Pharmaceuticals PLC, it is one of the most widely prescribed treatments in Bangladesh for gastrointestinal and systemic parasitic infections. This guide reflects the updated clinical standards and market prices for 2026.
What is Amodis 400 Used For?
Amodis 400 is primarily indicated for the treatment of infections caused by susceptible microorganisms:
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Amoebiasis & Giardiasis: Treatment of intestinal and extra-intestinal infections (such as liver abscesses) caused by parasites.
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Bacterial Vaginosis: Management of non-specific vaginitis in women.
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Anaerobic Infections: Treatment of serious infections including peritonitis, bone infections (osteomyelitis), and pelvic abscesses.
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Dental Infections: Relief from acute dental abscesses and ulcerative gingivitis (gum disease).
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Surgical Prophylaxis: Prevention of post-operative infections, particularly after abdominal or gynecological surgeries.
Clinical Note: While highly effective against bacteria and parasites, Amodis 400 is not effective for viral infections like the common cold or flu. For a technical review of the mechanism of action, visit the Metronidazole Pharmacology Overview on DrugBank.
Dosage
Dosage varies significantly based on the condition being treated. The following are standard adult guidelines:
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Amoebiasis: 400 mg to 800 mg three times daily for 5–10 days.
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Bacterial Vaginosis: 400 mg twice daily for 7 days, or a single 2g dose as directed.
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Dental Infections: 200 mg to 400 mg three times daily for 3–7 days.
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Administration: It is generally recommended to take the tablet during or after meals with plenty of water to minimize stomach upset.
Common Side Effects
Amodis 400 is effective but can cause distinct side effects in some patients:
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Metallic Taste: A very common, temporary bitter taste in the mouth.
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Gastrointestinal Issues: Nausea, vomiting, diarrhea, or epigastric pain.
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Neurological: Headache, dizziness, or drowsiness.
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Dark Urine: Patients should be aware that Metronidazole may cause urine to turn a darker reddish-brown color; this is harmless.
Professional Research Review: Alcohol Interaction
According to 2026 pharmacological updates, the “disulfiram-like reaction” remains a critical safety concern. Patients must strictly avoid alcohol during treatment and for at least 48 to 72 hours after the last dose. Mixing the two can lead to severe nausea, vomiting, rapid heartbeat (tachycardia), and flushing.
Important Warnings & Precautions
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Neuropathy Risk: Prolonged use or high doses may lead to peripheral neuropathy (numbness or tingling in extremities).
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Liver Disease: Use with caution and reduced dosage in patients with severe hepatic impairment.
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Pregnancy/Breastfeeding: Avoid use during the first trimester of pregnancy. Consult a doctor for use in later stages or while breastfeeding, as it passes into breast milk.
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Blood Disorders: Use with caution in patients with a history of blood dyscrasias (abnormal blood counts).
Amodis 400 vs. Entacyd Plus: Key Differences and Usage
Amodis treats the infection, while antacids like Entacyd Plus only manage the symptoms of acidity.
| Feature | Amodis 400 (Metronidazole) | Entacyd Plus (Antacid/Anti-gas) |
| Drug Class | Antibiotic / Antiprotozoal | Antacid / Antiflatulent |
| Primary Use | Killing parasites & bacteria | Heartburn, Gas, & Indigestion |
| Action Mechanism | Disrupts DNA of microbes | Neutralizes stomach acid |
| Alcohol Interaction | Severe reaction (Dangerous) | Generally safe |
| Unit Price | ৳2.00 | ৳2.50 – ৳3.50 |
Amodis 400 Price in Bangladesh (February 2026 Update)
Retail pricing for the Amodis range by Square Pharmaceuticals PLC remains affordable for the public.
| Product Name | Strength | Unit Price (BDT) | Strip Price (10 Tablets) |
| Amodis 400 | 400 mg | ৳2.00 | ৳20.00 |
| Amodis 200 | 200 mg | ৳1.20 | ৳12.00 |
| Amodis Suspension | 200mg/5ml | ৳35.00 (60ml) | N/A |
Amodis 400 Alternative Brands & Prices
Metronidazole is a widely available generic. Below are the top 10 alternatives in Bangladesh for 2026. Detailed lists can be found on Medex.com.bd.
| Brand Name | Company Name | Price per Unit (BDT) |
| Flagyl 400 | Synovia Pharma (Sanofi) | ৳1.70 |
| Filmet 400 | Beximco Pharmaceuticals | ৳1.70 |
| Metryl 400 | Opsonin Pharma | ৳1.70 |
| Dirozyl 400 | The ACME Laboratories | ৳1.70 |
| Metsina 400 | IBN SINA Pharma | ৳1.60 |
| Amotrex 400 | ACI Limited | ৳1.70 |
| Metro 400 | Ziska Pharmaceuticals | ৳1.50 |
| Biozyl 400 | Biopharma Ltd. | ৳1.70 |
| Anamet 400 | Navana Pharmaceuticals | ৳1.30 |
| Nidazyl 400 | Orion Pharma | ৳1.50 |
Frequently Asked Questions (FAQ) About Amodis 400
1. What is the Amodis 400 mg price in Bangladesh?
As of February 2026, the retail price is ৳2.00 per tablet. A full strip of 10 tablets costs ৳20.00.
2. What is Amodis 400 used for?
It is used to treat infections caused by bacteria and parasites, including diarrhea (amoebiasis), giardiasis, vaginal infections, and dental abscesses.
3. What are the common side effects of Amodis 400?
The most common side effects are a metallic taste in the mouth, nausea, headache, and dark-colored urine.
4. Is Amodis 400 safe during pregnancy?
It is generally avoided in the first trimester. It should only be used in later stages if prescribed by a physician who has weighed the risks.
5. Can I drink alcohol while taking Amodis 400?
No. You must avoid alcohol during treatment and for at least 3 days after finishing the course to avoid severe illness.
6. Is Amodis 400 used for loose motion/diarrhea?
Yes, it is highly effective if the diarrhea is caused by parasites (like amoeba) or certain bacteria, but it will not help with viral diarrhea.
7. Does Amodis 400 cause drowsiness?
Some patients may experience dizziness or sleepiness. If you feel dizzy, avoid driving or operating heavy machinery.
8. What is the dose for Amodis 400?
The standard adult dose is one 400 mg tablet two or three times daily, depending on the severity of the infection.
9. What are the best alternatives to Amodis 400?
Top alternatives include Flagyl 400 (Synovia), Filmet 400 (Beximco), and Metryl 400 (Opsonin), which are similarly priced.
Disclaimer: This information is for educational purposes only (updated February 2026). Antibiotics should only be taken under the supervision of a registered physician. Complete the full course even if symptoms disappear.
