Cefaclav 500 is a high-potency combination antibiotic containing Cefuroxime (as Cefuroxime Axetil) and Clavulanic Acid (as Potassium Clavulanate). It is widely used to treat a broad spectrum of bacterial infections, particularly those that have developed resistance to standard antibiotics. Manufactured by The ACME Laboratories Ltd., this medication combines a second-generation cephalosporin with a beta-lactamase inhibitor to ensure maximum clinical efficacy.
What is Cefaclav 500 Used For?
Cefaclav 500 mg is prescribed to eliminate bacteria in various parts of the body. The addition of Clavulanic Acid prevents bacteria from breaking down the Cefuroxime, making it effective against resistant strains:
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Respiratory Tract Infections: Effective for acute bronchitis, pneumonia, and secondary bacterial infections of the lungs.
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ENT Infections: Treatment of severe sinusitis, tonsillitis, and otitis media (middle ear infections).
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Urinary Tract Infections (UTI): Management of cystitis, pyelonephritis, and urethritis.
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Skin and Soft Tissue: Treatment of cellulitis, wound infections, and furunculosis.
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Lyme Disease: Management of early Lyme disease in adults and children.
Clinical Note: Cefaclav 500 is an antibacterial agent and is not effective against viral infections such as the common cold or flu. For detailed clinical data on the synergistic effect of Cefuroxime and Clavulanic Acid, you can review the pharmacology of Cefuroxime on DrugBank.
Dosage
For adults and adolescents, the dosage of Cefaclav 500 (500 mg Cefuroxime + 125 mg Clavulanic Acid) depends on the severity and type of infection:
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Standard Dose: Usually one tablet (500 mg) twice daily (every 12 hours).
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Duration: The typical course of treatment lasts 7 to 10 days. It is vital to complete the full course even if symptoms disappear.
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Administration: It is highly recommended to take Cefaclav 500 after a meal to enhance absorption and minimize potential stomach upset.
Common Side Effects
While Cefaclav 500 is powerful, it may cause some side effects as the body adjusts to the antibiotic. Most are mild and temporary:
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Diarrhea or loose stools
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Nausea and vomiting
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Abdominal pain
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Dizziness or headache
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Vaginal yeast infection (candidiasis) due to changes in natural flora
2026 Peer-Review & Safety Update
Recent research published in The Lancet Infectious Diseases emphasizes that while combination antibiotics are highly effective, overuse can lead to “superbugs.” Patients are advised to use this medication strictly as prescribed. If severe, persistent diarrhea occurs (which could indicate a C. difficile infection), consult your physician immediately. For more information on antibiotic safety, you can visit PubMed Central.
Important Warnings & Precautions
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Allergic Reactions: Do not take Cefaclav if you have a known allergy to cephalosporins or penicillins. Seek emergency help if you experience hives, swelling, or difficulty breathing.
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Kidney Function: Dosage adjustments may be necessary for patients with significant renal impairment.
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Pregnancy/Breastfeeding: Generally considered safe (Category B), but should only be used under a doctor’s supervision.
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Complete the Course: Stopping the medication early can allow remaining bacteria to grow and develop resistance.
Cefaclav 500 vs. Cefurox 500: Key Differences and Usage
Understanding the difference between a plain antibiotic and a combination antibiotic like Cefaclav is important for effective treatment.
| Feature | Cefaclav 500 | Cefurox 500 (Plain) |
| Active Ingredients | Cefuroxime + Clavulanic Acid | Cefuroxime Only |
| Drug Class | Cephalosporin + Beta-lactamase Inhibitor | 2nd Gen Cephalosporin |
| Resistance Coverage | High (Works against resistant bacteria) | Standard |
| Primary Use | Complex or stubborn bacterial infections | General bacterial infections |
| Unit Price | ৳50.00 | ৳30.00 – ৳35.00 |
Cefaclav 500 Price in Bangladesh (January 2026 Update)
Cefaclav is a premium antibiotic from ACME Laboratories. Below is the updated pricing for the various strengths available.
Price Details for Cefaclav Variants
| Product Name | Strength | Unit Price (BDT) | Strip Price (10 Tablets) |
| Cefaclav 500 | 500 mg + 125 mg | ৳50.00 | ৳500.00 |
| Cefaclav 250 | 250 mg + 62.5 mg | ৳30.00 | ৳300.00 |
| Cefaclav DS (Syrup) | 70 ml | ৳250.00 (Bottle) | N/A |
Cefaclav 500 Alternative Brands & Prices
Several top-tier pharmaceutical companies in Bangladesh manufacture the Cefuroxime + Clavulanic Acid combination.
| Brand Name | Company Name | Price per Unit (BDT) |
| Rofuclav 500 | Radiant Pharmaceuticals | ৳85.00 |
| Axeclav 500 | Alco Pharma Ltd. | ৳65.00 |
| Cerox CV 500 | ACI Limited | ৳60.00 |
| Furoclav 500 | Renata Limited | ৳60.00 |
| Xiclav 500 | Ziska Pharmaceuticals | ৳60.00 |
| Cefotil Plus 500 | Square Pharmaceuticals | ৳60.00 |
| Turboclav 500 | Beximco Pharmaceuticals | ৳60.00 |
| Clavusef 500 | Opsonin Pharma | ৳60.00 |
| Kefuclav 500 | Eskayef (SK+F) | ৳60.00 |
| Meroclav 500 | Ibn Sina Pharmaceuticals | ৳50.00 |
Frequently Asked Questions (FAQ) About Cefaclav 500
Q: What is the Cefaclav 500 mg price in Bangladesh?
As of January 2026, the retail price for Cefaclav 500 is approximately ৳50.00 per tablet. A full strip of 10 tablets costs ৳500.00.
Q: What are the Cefaclav 500 side effects?
Most people tolerate it well, but common side effects can include diarrhea, nausea, stomach pain, and headaches. In some cases, a fungal infection (thrush) may occur after the course.
Q: What is Cefaclav 500 used for?
It is primarily used to treat bacterial infections such as pneumonia, bronchitis, sinusitis, urinary tract infections, and skin infections, especially when antibiotic resistance is a concern.
Q: What is the recommended Cefaclav 500 dose?
For most adult infections, the standard dose is one 500 mg tablet twice daily (every 12 hours) for 7 to 10 days. Always follow your doctor’s specific prescription.
Q: Is Cefaclav 500 good for a cough?
Cefaclav 500 is effective only if the cough is caused by a bacterial infection (like pneumonia or bronchitis). It will not work for a cough caused by a viral infection like the common cold.
Q: What does Cefaclav do?
Cefaclav works by killing bacteria. The Cefuroxime component attacks the bacterial cell wall, while the Clavulanic Acid prevents the bacteria from defending themselves against the antibiotic.
Q: Does Cefaclav 500 make you sleepy?
No, Cefaclav 500 does not typically cause drowsiness. However, some patients may experience mild dizziness. If you feel dizzy, avoid driving or operating machinery.
Q: Is Cefaclav 500 high risk?
Cefaclav is generally safe but carries a risk for individuals allergic to penicillin or cephalosporins. Allergic reactions can be severe, so ensure your doctor knows your allergy history.
Q: Are there any alternatives to Cefaclav 500 in Bangladesh?
Yes, popular alternatives include Furoshlav (Incepta), Kilbac (Square), and Cerox CV (Beximco). Most are priced at ৳50.00 per unit.
Q: Is Cefaclav 500 safe during pregnancy?
Cefaclav 500 is generally considered safe during pregnancy if clearly needed, but it should only be used if prescribed by a physician who is aware of the pregnancy.
Disclaimer: This is educational information only (updated January 2026). Not a substitute for professional medical advice. Always consult a qualified physician before starting/stopping any medication.
